Structural Basis of Nav1.7 Inhibition by the Tarantula Toxin Protoxin-II
نویسندگان
چکیده
منابع مشابه
Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.
ProTx-II, an inhibitory cysteine knot toxin from the tarantula Thrixopelma pruriens, inhibits voltage-gated sodium channels. Using the cut-open oocyte preparation for electrophysiological recording, we show here that ProTx-II impedes movement of the gating charges of the sodium channel voltage sensors and reduces maximum activation of sodium conductance. At a concentration of 1 microM, the toxi...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.1687